AIM HIGH media takeaway: don't take niacin

in the news this week: niacin study stopped early after lack of benefit found, and perhaps even negative benefit found.

e.g. this MSNBC headline states, "Niacin doesn't stop heart attacks, major study finds"

i read the press release. The second sentence of the press release is:

The trial found that adding high dose, extended-release niacin to statin treatment in people with heart and vascular disease, did not reduce the risk of cardiovascular events, including heart attacks and stroke.

we know straightaway that the combination of niacin with a statin (or two, depending on the subject) did not reduce cardiovascular events. the MSNBC article did state this in the body, so bad on them for sloppy headline writing.

further down in the press release:

The DSMB also noted a small and unexplained increase in ischemic stroke rates in the high dose, extended-release niacin group. This contributed to the NHLBI acting director’s decision to stop the trial before its planned conclusion. During the 32-month follow-up period, there were 28 strokes (1.6 percent) reported during the trial among participants taking high dose, extended-release niacin versus 12 strokes (0.7 percent) reported in the control group. Nine of the 28 strokes in the niacin group occurred in participants who had discontinued the drug at least two months and up to four years before their stroke.

Interesting. Twenty-eight strokes are being correlated with niacin intake, though they might consider counting only 19. I have to wonder if 12 vs 19 is statistically significant.

There were a couple pieces of information missing from the press release. I would like to know how many strokes there were in the control group, to compare against the 12, 19, or 28. I would also like to know the numbers for the other cardiovascular events. They were mentioned, but never enumerated, and MSNBC's headline writer either knows something not in the press release, or took some liberties.

I also noted this bit:

The niacin tested in the study is a proprietary formulation used in doses of 500-2,000 milligrams (mg), manufactured by Abbott Laboratories and approved and regulated by the U.S. Food and Drug Administration.

I thought Niaspan was simply niacin. perhaps "proprietary formulation" means nothing more than a manufacturing process -- and a way to patent an easily available vitamin -- but if it's anything other than straight niacin, i think that's relevant.

finally, this made me laugh:

Eligible participants were randomly assigned to either high dose, extended-release niacin (Niaspan) in gradually increasing doses up to 2,000 mg per day (1,718 people) or a placebo treatment (1,696 people).

I wonder if the placebo also caused a flushing effect. otherwise, that's not terribly blind.

a physics joke

Einstein walks ten miles to a party. When he arrives, the host says, "wow, you spent a lot of energy getting here."

Einstein replies, "es machts nicht."

we're gonna xooma xooma, xoom xoom xoom

mere days after telling my boss that between my iphone and macbook pro, i have no need for a tablet, all employees were presented with Motorola Xooms (oops).

this is not only my first experience with a tablet, other than a few minutes with an ipad, but it's also my first experience with Android. the xoom comes with a version called Honeycomb, which i'm told is new and designed with tablets in mind.

the hardware is nice. a good size, solid, with a reasonably sharp screen. after comparing its size directly to that of an ipad, i found that the ipad is just a tad bit wider, making a big difference in how it sits in my lap. oddly, after using the xoom in my lap for a while, i discover that my abs are sore. with the ipad's tapered edge and better shape, even though the dimensional differences are slight, i do find the ipad works better in this regard.

rear camera: no better than my iphone 3gs in a couple test shots, despite the greater megapixel count (not that i put a lot of stock into that). power button: badly placed! Not only can i not find it when i want, smudging up the rear camera lens instead, but i find i'm constantly hitting it during normal use and shutting off the screen.

i also find i don't like the "neat" feature that the xoom can be used in any orientation. i like that my iphone has a button on the front, so i know which way is "up". on the xoom, any way you want is "up" -- until you need to find the power button or adjust the volume. then it's not so neat.

software-wise, i can't say i'm the biggest fan of the Android user-experience. new version glitches aside (and there are many, from brief image glitches to constant crash problems with the browser and facebook app), i find it looks better than iOS, but isn't nearly as intuitive.

there are navigation buttons on the lower-left that do have some nice features. the home button is styled as navigation button, pointing up, demonstrating some nice consistency with the "go left" button. a very nice navigation feature is that the go-left button always takes you where you came from, even if you came from a different app. it's a nice switching feature that i think iOS could benefit from. further, if you're in some kind of pop-up form, that button changes to "go down" to dismiss that form.

however, i wish the buttons were in the upper-left of the screen, closer to where my fingers are. navigation ends up being about as comfortable as hitting ctrl-z on a keyboard with your left hand.

i think Motorola had a bit of a goof on the homepage, as well. out of the box, the homepage has a cool iridescent clock in the center, with a small collection of app icons laid out horizontally below (browser, gmail, android market [i.e. app store] et. al.). It's a nice look.

But when you go to market and download your first app, by default it places it on your homepage in the first open spot, which is in the upper-left of the screen. it looks completely out of place, and congratulations you've already ruined the drama of turning on the device.

speaking of which, upon power-up, after an initial splash screen, you're presented with a horrific, eye-straining honeycomb animation that plays during boot up. it's pretty awful in any light, but if you've been using the tablet in the dark for a while, and need to reboot it (e.g. the browser likes to stop pretending there's an internet every 10 minutes or so, and i've yet to find a way to restart an app sans a reboot), the honeycomb animation can be nothing short of blinding.

the other night, in a fit or pure optimism, i broke out the USB cable and plugged the xoom into my laptop. i expected... something? iTunes to launch? a desktop icon? maybe even an offer to sync contacts and music?

silly me. nothing happened. at all. after some googling, failed experiments with DoubleTwist, and more googling, i was able to get my contacts on my Xoom by first exporting a vcard from Address Book and uploading it to GMail. hardly a "sync". i was able to transfer music by using an app that opens up the Xoom's file system on the laptop. yuck.

still, with all these issues, i find that i'm using it at home for many things i typically do with my laptop. and if i'm being honest, i'm also finding my year-old macbook pro feels a little... old-fashioned.

i will be doing some programming for the xoom (on my laptop, natch), which in Eclipse I expect will be a more pleasant, or at least familiar, exercise than using apple's iOS IDE.

from a pure user's perspective though, i strongly suspect i would be happier with an ipad.

alliteration

"sweet sixteen"
"final four"

i'm sorry, but "elite eight" is not an alliteration, and it sounds forced and a little clumsy. either make it actually alliterative ("able eight"?) or just make it better without the alliteration ("great eight").

unless we're going to carry it all the way down ("terrific two"? "wonderful one"?), feel free to break out of the literary device.

i am in awe of the GOP

i am in awe of the GOP, for mostly two reasons. first is their ability to consistently get people to vote against their own interests. second is their ability to control the debate and get their way, even when in the minority.

the recent events in Wisconsin and Michigan highlight recent brazen attempts at power grabs and attacks on democrats' power bases that underscore what i see as outright contempt for the idea of balancing forces and governing for the people.

it's an amazing Big Lie in action. during GW Bush's two terms, i was amazed at how the GOP could sell the idea that running huge deficits was actually good for the economy. right around the day Obama took office, we saw a complete 180 on how deficits are destroying the economy. to the surprise of no one (i hope), the GOP turned their attention to slashing the budgets of items that run counter to GOP ideology.

in Wisconsin, take that a step further to weaken democratic power bases, such as organized labor. heck, in this instance, be sure to exclude organized labor that voted for you (police and fire unions). that this is political payback and an attack should be obvious, yet the GOP still (mostly) frames the debate that this is about balancing budgets.

there's a lot of noise being made by a large number of people who see through all this and i'm even hearing talk of an illegal, general strike in Wisconsin. side note: apparently this might include the fire fighting unions, at which point firefighters should prepare to have their own collective bargaining rights eliminated.

despite the noise, and even in the event that Governor Walker is eventually removed from or voted out of office, i see this as the opening salvo in a sustained and eventually successful effort by the GOP to become the dominant party for decades.

if the GOP can succeed in destroying the fundraising bases of the dems, and if the GOP can succeed in ensuring that public education is ineffective, and if the GOP can continue succeeding in those two things of which i am in awe... what is left to stop the GOP?

imho, it can only be a splintering of the party. though i hear grumblings within the GOP about elected tea party officials maybe over-reaching, i'm not yet seeing anything resembling a parental smackdown.

the election of Obama left me hopeful, though that hope has all but faded. i see his election as the last hurrah of the liberal left (side note: well done to the GOP for painting the words "liberal" and "social" in such a negative light), an earth-moving event for which calls of "general strike" are mere aftershocks.

maybe i'm too soon declaring the patient dead, but i fear the best days of the United States are behind it.

the ideology of dogs

Shelley Boyle says having a vegan food option for her dog, Cleo, allows them to share the same ideology.

oy, ve.

can we get a quote from the dog, please?

amazing true stories of the Blizzard of 2011

i know they're true, because i saw them on the TV.

1. this evening, the local ABC news reported on a woman who would NOT BE STOPPED as she needed to get her child to a doctor's appointment. the anchors spoke of her ingenuity and great spirit, as she put her child on a plastic sled and dragged her TWO ENTIRE BLOCKS to a COMPLETELY FUNCTIONAL CTA RAIL SYSTEM which took her to the hospital. amazing!

2. last night, the local NBC news introduced a new Storm Tracker Technology, praised several times by the anchors while saying "Storm Tracker Technology" in obvious initial caps. this new technology allowed us at-home viewers to experience what it would be like to travel the local expressways in this storm. They accomplished this by driving a news van on the expressway and POINTING A VIDEO CAMERA OUT THE FRONT WINDSHIELD. amazing!

i am continually amazed by the human spirit.